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Amikacin Sulfate

Amikacin sulfate is a broad-spectrum aminoglycoside antibiotic derived from kanamycin.1 Amikacin is active in vitro against Pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella, Enterobacter, Serratia, Acinetobacter (formerly Mima-Herellea) species and Citrobacter freundii.2 It acts by inhibiting protein synthesis. It is inactive against fungi, viruses and most anaerobic bacteria.3

While parenteral use is only approved in dogs, amikacin is used clinically to treat serious Gram-negative infections in most species. It is often used in settings where gentamicin-resistant bacteria are a clinical problem. Amikacin is also approved for untrauterine infusion in mares. This drug should be used with extreme caution in patients with preexisting kidney disease.3

  1. PubChem Compound Database
  2. Amikacin sulfate
  3. Veterinary Drug Handbook. Donald C. Plumb



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