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Furazolidone

Furazolidone is a nitrofuran antibiotic used as a local antibacterial and antiprotozoal. In dogs, horses, and ponies furazolidone is used for treatment or prevention of bacterial infection of superficial wounds, abrasions, lacerations, and pyogenic dermatitis. 1

In dogs and cats furazolidone is also used for amebic colitis, coccidiosis, giardiasis, and entamebiasis. 3

Furazolidone acts by gradual inhibition of monoamine oxidase. Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome. 2

Furazolidone has activity against Giardia, Vibrio cholerae, Trichomonas, Coccidia and many strains of E. coli, Enterobacter, Campylobacter, Salmonella, and Shigella. 3

Possible side affects include vomiting, diarrhea, loss of appetite and cramping.

References:
REF FILE 324-DAC

 




 


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