Megestrol acetate is a synthetic progestational steroid hormone (progesterone) which has the same physiologic effects as natural progesterone. It is used in female dogs for postponement of estrus and the alleviation of false pregnancy. Megestrol also has direct cytotoxic effects on cancer cells. In male dogs the drug is used for the treatment of benign prostatic hypertrophy.1
In cats megestrol acetate is prescribed for the treatment of miliary dermatitis and eosinophilic granuloma.
Megestrol acetate is not used in pregnant animals, prior or during first estrus cycle, or in the presence of a disease of the reproductive system or with mammary tumors. 2
This drug is not used in stressed cats as it may help cause adrenocortical suppression and diabetic retinopathy (after long-term use). In cats, megestrol acetate may also temperament changes (aggression, depression, increased affection) increased appetite with weight gain. 4
REF FILE 324-DAC