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Nitenpyram

Nitenpyram is an oral insecticide used primarily to kill adult fleas in dogs and cats. It is not effective alone for flea eggs or other immature forms. 1

Mechanism of Action

Nitenpyram is a nitromethylene neonicotinoid agent which binds to nicotinic acetylcholine receptors in the postsynaptic membranes and blocks acetylcholine mediated neuronal transmission causing paralysis and death of the parasite. Efficacy appears to be greater than 95% (kill rate) in dogs and cats within 6 hours of treatment. 1

Nitenpyram (Capstar® tablets) is approved by the FDA For the treatment of flea infestations in dogs, puppies, cats, and kittens. The concurrent use of flavored Lufenuron tablets with nitenpyram tablets is indicated to kill adult fleas and prevent flea eggs from hatching.

Nitenpyram is a component of Sentinel® Flavor Tabs® and Capstar® Flea Management System™ veterinary drugs (lufenuron, nitenpyram, milbemycin oxime) used in dogs and puppies to kill adult fleas and prevent flea eggs from hatching. 2

Nitenpyram is not used in animals under 4 weeks of age or under 2 pounds of body weight. 1

Nitenpyram is a component ofProgram® Flavor Tabs® and Capstar® Flea Management System™ (lufenuron, nitenpyram) is used in dogs and cats kill adult fleas and prevent flea eggs from hatching.

Nitenpyram can be administered on any day when fleas are seen. No more than one treatment should be given per day. Products to control immature stages (eggs) are required to prevent re-infestation. 3

In addition to the common nuisance irritations associated with infestations, fleas can be responsible for skin conditions in your pet such as flea allergy dermatitis (FAD) in the dog and miliary dermatitis in the cat. Also, fleas transmit other parasites, including tapeworms. The control of flea infestations is important to your pet's health and also reduces the problems associated with these parasites.

Nitenpyram Side Effects

Nitenpyram is usually tolerated well. It is relatively safe at high doses to mammals. 1 The following adverse reactions have been reported in dogs after giving PROGRAM Flavor Tabs: vomiting, depression/lethargy, pruritus (itchy, scratchy skin), urticaria (wheals, hives), diarrhea, anorexia (loss of appetite), and skin congestion (red skin). 6


References:
REF FILE 324-DAC



 



 


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