Chlorogenic Acid

Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet.

Chlorogenic acid is a naturally occurring phenolic acid, one of the most abundant polyphenols in fruits, which is a carcinogenic inhibitor. It has also been shown to prevent oxidative stress in animal experiments. It demonstrated anticancer activity in cancerous neoplasms of the colon, liver, brain, mouth and skin. Animal studies suggest that chlorogenic acid has a chemopreventive effect on glandular stomach cancer and it may be a promising agent for prevention of human stomach cancer.

Oxidative stress is linked to neurodegenerative diseases, cancer, cardiovascular diseases and to some behaviors, such as anxiety and depression. In particular, recent research observed a close relationship between oxidative stress and anxiety. Chlorogenic acid has reduces anxiety and has antioxidant activity. Fruits such as plums (Mirabelle), and cherries may provide health-promoting advantages.

Plants with high amount of chlorogenic acid: coffee arabica (seed), sunflower (seed), Damask Rose (pollen), blueberries, cilantro, tomatoes, peanuts, potatoes.


  1. Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects. Bouayed J, Rammal H, Dicko A, Younos C, Soulimani R.
  2. The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression. Belkaid A, Currie JC, Desgagn├ęs J, Annabi B.
  3. Induction of cytotoxicity by chlorogenic acid in human oral tumor cell lines. Jiang Y, Kusama K, Satoh K, Takayama E, Watanabe S, Sakagami H.
  4. Suppressive effects of chlorogenic acid on N-methyl-N-nitrosourea-induced glandular stomach carcinogenesis in male F344 rats. Shimizu M, Yoshimi N, Yamada Y, Matsunaga K, Kawabata K, Hara A, Moriwaki H, Mori H.